1. Exploitation and evaluation of pig genetic resources
Functional genomics studies were carried out on important economic traits of pigs (skeletal muscle growth and fat deposition) to explore genomic variation loci hidden under traditional phenotypic selection and screen candidate genes.
2. Molecular basis and genetic regulation of important economic traits in pigs
Functional genomics studies were carried out on important economic traits of pigs (skeletal muscle growth and fat deposition) to explore genomic variation loci hidden under traditional phenotypic selection, screen candidate genes, and identify regulatory mechanisms. We use multi-omics techniques (including Bulk RNA-seq, single-cell transcriptome, spatial transcriptome, Hic 3D genomics, etc.) to analyze the genetic and regulatory mechanisms of traits from different perspectives.
3. Using gene editing technology to improve important economic traits
Editing the non-coding regions of the genome can significantly improve the production and economic traits of pigs (improve muscle growth and reduce fat deposition). This method does not introduce any foreign genes or DNA fragments, nor does it affect the coding sequence of endogenous genes. The expression level of important genes is regulated by modifying the non-coding regions. It can improve the growth rate without changing the characteristics of the original variety, and provides a new idea and strategy
for precise breeding.
4. Exploration and utilization of pig symbiotic microbial resources
Symbiotic microbiota are closely related to host life activities such as growth performance, immunity, and environmental adaptability. In our lab, we used 16S/ITS amplicons sequencing, metagenomics and metametabolomics to investigate the gut microbiota of pigs in various aspects, to discover the gut microbiota resources closely related to breeds and important economic traits, and to further explore the interaction mechanism between the microbiota and the host.
